Should I be worried about my friend self-destructing himself? Seriously. Please help with advice.?

Hi all. I tried calling a friend of mine recently but his number had been changed. He also blocked his Facebook account from being seen from everybody. Since I had no other options, I visited him at his house hoping he would be there. He opened the door and I was shocked. He looks like he weighs over 350lbs. (his Massive fat weight gain is very noticeable), hardly talks and slowly moves. He looked very depressed and sad to me. His Mom was with him when I showed up. His Dad was out somewhere. He hardly talked to me and went up to his room almost as soon as I said hi. She told me after his breakup with his ex-girlfriend (she cut off contact with him after she found another guy), he basically let himself go. When I last saw him a little over a year ago, he was a lean, strong 170lbs. with a 32" waist. Many girls were after him for a date. I knew about the breakup with his ex-girlfriend but I thought he would be fine by now. His Mom said he hardly works and stays in his room most of the time, eats a lot, and takes sleeping pills. She said he hasn't been the same since then. I left after he said he didn't want to talk to me but he said it in a nice way. I'm worried about him committing suicide. Should I be worried about my friend self-destructing himself? Seriously. Please help with advice. Any answers would be appreciated. Thanks.